An application of Ameela results in a histological change of fibroblasts, osteoblasts, and adipocytes, as well as other structures in the tissue (bio-structuring in all tissue layers such as bone, muscle and adipose tissue). It changes the structures from fibroblasts to myofibroblasts, which is a phenotype intermediate between fibroblasts and smooth muscle cells - i.e. a modulation of the fibroblasts. This means positive effects are seen quickly - and a lift in skin structure is visible after just a few minutes.

Polymeric macromolecules result in an immediate “scavenger” action against free radicals. The chemical structures of the nitrogenous ring on the polynucleotides immediately reacts with free radicals, which neutralises them. When the polynucleotides molecule is being degraded by the body's own enzymes, smaller particles which retain the same properties as the whole Polynucleotide molecule.

The progressive degradation of polynucleotide molecules by enzymes present in the extracellular environment frees up the metabolites which, in turn, accentuates the protection activity against free radicals.